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Nervous system --- Nervous system --- Diseases. --- Diseases.
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Nervous System --- Nervous System Diseases --- anatomy & histology
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"Compared with other disease areas, central nervous system (CNS) disorders have had the highest failure rate for new compounds in advanced clinical trials. Most CNS drugs fail because of efficacy, and the core issue underlying these problems is a poor understanding of disease biology. Concern about the poor productivity in neuroscience drug development has gained intensity over the past decade, amplified by a retraction in investment from the pharmaceutical industry. This retreat by industry has been fueled by the high failure rate of compounds in advanced clinical trials for nervous system disorders. In response to the de-emphasis of CNS disorders in therapeutic development relative to other disease areas such as cancer, metabolism, and autoimmunity, the National Academies of Sciences, Engineering, and Medicine initiated a series of workshops in 2012 to address the challenges that have slowed drug development for nervous system disorders. Motivated by the notion that advances in genetics and other new technologies are beginning to bring forth new molecular targets and identify new biomarkers, the Academies hosted the third workshop in this series in September 2016. Participants discussed opportunities to accelerate early stages of drug development for nervous system disorders in the absence of animal models that reflect disease and predict efficacy. This publication summarizes the presentations and discussions from the workshop"--
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Nervous system --- Diseases --- Treatment.
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Peu à peu, le champ de la neurologie réinvestit la cognition et le comportement, dont l'évaluation rapide fait partie de l'examen neurologique au même titre que celle de la marche ou des réflexes ostéo-tendineux. Ce deuxième volume du GRÉMOIRE présente donc de nouveaux outils consensuels validés pour l'évaluation des troubles à symptomatologie cognitive. Leur regroupement sous l'étendard de la neurologie, dans la mouvance du plan gouvernemental « maladies neurodégénératives », participe à la compréhension de la neuropsychologie (fonction, réseau de neurones, clinique) de façon holistique et consensuelle. Pour chacun des tests, des échelles, des questionnaires et des batteries, les auteurs proposent une présentation historique, suivie d'un guide d'utilisation qui permettra au lecteur de comprendre le fonctionnement de l'outil qui l'intéresse. Certains tests, comme le Mini Mental Parkinson (MMP), l'Informant questionnaire on cognitive decline in the elderly (IQCODE), ou encore le test des commissions révisé, sont reproduits dans leur totalité, avec l'autorisation des auteurs concernés. Cet ouvrage collectif, réunissant chercheurs et cliniciens, est le fruit du travail des membres du groupe de réflexion sur les évaluations cognitives (GRECO).
Nervous system --- Examinations. --- Diseases.
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Neuroscience is an evolving, complex, and multidisciplinary field of medicine. Neuroradiologists and neuropathologists are an important part of the multidisciplinary team in addition to neurosurgeons, neurologists, and other disciplines. Featuring over nine hundred images, this practical textbook and atlas combines the specialties of neuroradiology and neuropathology, providing an extensive understanding of the disease process. It offers a comprehensive review of the nervous system diseases, including eye, skeletal muscle, and bone and soft tissue diseases. Topics are covered in chapters arranged by region, allowing for quick reference of conditions such as brain tumors, spinal cord diseases, or congenital malformations. Introductory chapters on pathologic and radiologic techniques are also featured, enabling specialists of both areas to familiarize themselves with the other's subject. Packaged with a password to give the user online access to all the text and images, this is a must-have resource for comprehensive and accurate diagnosis.
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Nervous System Diseases. --- Nervous system --- Système nerveux --- Diseases. --- Maladies
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